Prostate-Specific Antigen Levels in Women with Colorectal Cancer
Author Information
Author(s): Duraker N, Can D, Parıltı M
Primary Institution: SSK Okmeydanı Training Hospital, İstanbul, Turkey
Hypothesis
What is the diagnostic value of total and free prostate-specific antigen in women with colorectal carcinoma?
Conclusion
Free prostate-specific antigen levels are significantly higher in women with colorectal carcinoma compared to healthy women, indicating potential clinical significance.
Supporting Evidence
- Free prostate-specific antigen levels were significantly higher in women with colorectal carcinoma than healthy women.
- The percentage of free prostate-specific antigen predominant subjects was 20% in colorectal carcinoma patients and 3.3% in healthy women.
- Total prostate-specific antigen positivity was 20% and free prostate-specific antigen positivity was 34.6% in women with colorectal carcinoma.
Takeaway
This study looked at blood tests for a protein called prostate-specific antigen in women with colorectal cancer and found that those with cancer had higher levels than healthy women.
Methodology
Serum total and free PSA levels were measured preoperatively in 75 women with colorectal carcinoma and 30 healthy women using immunoradiometric assay.
Potential Biases
Potential selection bias due to the study being conducted at a single hospital.
Limitations
The study had a small sample size and was limited to a single institution.
Participant Demographics
75 women with colorectal carcinoma (mean age 60 years) and 30 healthy women (mean age 40.4 years).
Statistical Information
P-Value
0.006 for free PSA levels, 0.035 for free PSA predominancy.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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