Increased Resistance to Amoxicillin-Clavulanic Acid in E. coli in Spain
Author Information
Author(s): Oteo Jesús, Campos José, Lázaro Edurne, Cuevas Óscar, García-Cobos Silvia, Pérez-Vázquez María, de Abajo F. J.
Primary Institution: Instituto de Salud Carlos III, Madrid, Spain
Hypothesis
What are the trends of amoxicillin-clavulanic acid resistance among E. coli isolates in Spain?
Conclusion
The study found a concerning increase in amoxicillin-clavulanic acid resistance among E. coli blood isolates in Spain, coinciding with increased community consumption of the drug.
Supporting Evidence
- 1,136 out of 9,090 E. coli isolates were nonsusceptible to amoxicillin-clavulanic acid.
- The prevalence of resistance increased from 9.3% in 2003 to 15.4% in 2006.
- Multidrug resistance was found in 17.4% of nonsusceptible isolates.
- Community-acquired infections showed a higher increase in resistance compared to hospital-acquired infections.
Takeaway
Doctors are finding that a common medicine, amoxicillin-clavulanic acid, is becoming less effective against a type of bacteria called E. coli in Spain, which is worrying.
Methodology
The study tested 9,090 blood isolates from 42 Spanish hospitals and compared resistance trends with outpatient consumption data.
Limitations
The study may not account for all factors influencing resistance, such as other antibiotic use or local healthcare practices.
Participant Demographics
49.8% male and 50.2% female patients, with a range of ages including children and older adults.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI 1.08–1.39
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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