Retinol Levels in Colorectal Cancer Patients After Surgery
Author Information
Author(s): T.K. Basu, U.M. Chan, A.L.A. Fields, T.A. McPherson
Primary Institution: The University of Alberta
Hypothesis
Are low plasma levels of retinol and its carrier related to increased risk of cancer recurrence in postoperative colorectal cancer patients?
Conclusion
Postoperative colorectal cancer patients have lower plasma retinol and retinol-binding protein levels compared to healthy individuals, which may be linked to cancer recurrence.
Supporting Evidence
- Patients with colorectal cancer had lower plasma retinol levels compared to healthy controls.
- Lower retinol levels were associated with a higher risk of cancer recurrence.
- Two patients who died during the study had the lowest retinol levels recorded.
Takeaway
This study found that patients who had colorectal cancer surgery had lower levels of a vitamin called retinol in their blood, which might mean they are more likely to get cancer again.
Methodology
Blood samples were taken from patients to measure plasma levels of retinol and retinol-binding protein.
Potential Biases
Potential bias in using healthy blood donors as controls.
Limitations
The control group was not ideal as they were healthy blood donors, and the study only included patients who had undergone surgery.
Participant Demographics
103 patients, 66 with Dukes' B2 tumours and 37 with Dukes' C tumours, mean age 62.6 years.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.001
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