CD44v6 and Local Recurrence in Soft Tissue Sarcomas
Author Information
Author(s): Maula S, Huuhtanen R L, Blomqvist C P, Wiklund T A, Laurila P, Ristamäki R
Primary Institution: Helsinki University Central Hospital
Hypothesis
The study investigates the clinical significance of CD44 and its variant CD44v6 in adult soft tissue sarcomas.
Conclusion
High expression of CD44 and CD44v6 is linked to a greater risk of local recurrence in soft tissue sarcomas.
Supporting Evidence
- 95% of the tumors expressed CD44 and 57% expressed CD44v6.
- Strong CD44 expression was associated with low grade and small tumor size.
- In diploid tumors, CD44 expression correlated with low S-phase fraction.
- High expression of CD44 predicted a higher risk for local recurrence.
- Low CD44v6 content correlated with poor survival.
Takeaway
This study found that certain markers in tumors can help doctors know which patients might need more treatment to prevent their cancer from coming back.
Methodology
The expression of CD44 and CD44v6 was determined immunohistochemically on paraffin-embedded tumor samples from patients treated at a hospital.
Participant Demographics
Patients with limb or superficial trunk tumors treated at Helsinki University Central Hospital between 1987 and 1993.
Statistical Information
P-Value
P = 0.01 and P = 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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