Orodispersible Films for PROTAC ARV-110 Delivery
Author Information
Author(s): Valentina Meloni, Laura Halstenberg, Lena Mareczek, Jankin Lu, Bonnie Liang, Nadine Gottschalk, Lena K. Mueller
Primary Institution: Merck Life Science KGaA
Hypothesis
The study aims to enhance the solubility of PROTAC ARV-110 through the formulation of orodispersible films (ODFs) using hot melt extrusion and solvent casting.
Conclusion
The study successfully produced orodispersible films that significantly enhance the solubility and dissolution of PROTAC ARV-110.
Supporting Evidence
- All formulations demonstrated enhanced solubility of ARV-110.
- The films created through hot melt extrusion showed a disintegration time of around 86 seconds.
- The solvent casting method produced films with disintegration times around 30 seconds.
- Dissolution tests indicated a significant increase in drug release compared to the crystalline form.
- Adding triacetin as a plasticizer improved the flexibility and dissolution of the films.
- Both methods provided a foundation for further exploration of orodispersible films for PROTAC delivery.
Takeaway
This research shows how to make special films that dissolve in your mouth to help deliver a medicine called ARV-110, which is hard to dissolve in water.
Methodology
The study used hot melt extrusion and solvent casting to create orodispersible films, which were characterized for disintegration, dissolution, and mechanical strength.
Limitations
The study's results may not be directly comparable due to variations in test setups and limited availability of the API.
Digital Object Identifier (DOI)
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