Atopic Dermatitis and the Atopic March: What Is New?
Author Information
Author(s): Annalisa Patrizi, Alessandro Pileri, Federica Bellini, Beatrice Raone, Iria Neri, Giampaolo Ricci
Primary Institution: University of Bologna
Hypothesis
The study investigates the relationship between atopic dermatitis (AD) and the development of allergic respiratory diseases.
Conclusion
The study concludes that an impaired epidermal barrier is a key factor in the onset of the atopic march, leading to increased skin permeability to allergens.
Supporting Evidence
- Atopic dermatitis is often the first sign of allergic diseases in children.
- Filaggrin gene mutations are linked to a higher risk of developing atopic dermatitis.
- Studies show that children with atopic dermatitis have a significantly increased risk of developing asthma.
Takeaway
Atopic dermatitis can lead to other allergies like asthma because it makes the skin more sensitive to things that can cause allergic reactions.
Methodology
The authors reviewed literature from PubMed databases over the last 15 years and analyzed various studies on atopic dermatitis and its association with allergic diseases.
Limitations
The study highlights the need for further research to clarify the mechanisms linking atopic dermatitis to respiratory allergies.
Participant Demographics
The study involved families with a history of atopic dermatitis, focusing on genetic factors related to filaggrin mutations.
Digital Object Identifier (DOI)
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