Liver Enzymes and Type 2 Diabetes Risk
Author Information
Author(s): Tohidi Maryam, Harati Hadi, Hadaegh Farzad, Mehrabi Yadolladh, Azizi Fereidoun
Primary Institution: Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University, Tehran, Iran
Hypothesis
Are liver enzymes associated with the risk of developing type 2 diabetes in an Iranian population?
Conclusion
ALT is associated with incident type 2 diabetes independent of classic risk factors, but adding it to the classic risk factors does not improve diabetes prediction.
Supporting Evidence
- ALT and GGT were associated with diabetes in univariate analysis.
- After adjusting for various factors, only ALT remained significantly associated with diabetes.
- The addition of ALT did not significantly improve the predictive power of classic risk factors.
Takeaway
This study found that a liver enzyme called ALT can help predict if someone might get type 2 diabetes, but it doesn't make the predictions any better than just looking at other risk factors.
Methodology
A nested case-control study measuring liver enzymes and diabetes risk factors in 133 non-diabetic subjects, with 68 cases and 65 controls.
Potential Biases
Potential bias due to the small sample size and exclusion of certain health markers.
Limitations
Small sample size and lack of measurement for hepatitis B and C markers.
Participant Demographics
Participants were non-diabetic individuals from the Tehran Lipid and Glucose Study, aged over 20 years.
Statistical Information
P-Value
0.4
Confidence Interval
1.02–9.86
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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