SCOWLP classification: Structural comparison and analysis of protein binding regions
2008
Classification of Protein Binding Regions
Sample size: 2561
publication
Evidence: moderate
Author Information
Author(s): Teyra Joan, Paszkowski-Rogacz Maciej, Anders Gerd, Pisabarro M Teresa
Primary Institution: BIOTEC TU-Dresden
Hypothesis
A proper classification of protein binding regions can facilitate the analysis of protein interactions.
Conclusion
The SCOWLP classification provides a framework for studying protein interfaces and comparative analysis of binding regions.
Supporting Evidence
- The SCOWLP database contains detailed interfacial information of protein complexes.
- 65% of protein families contain more than one binding region.
- The classification allows for flexible analysis of protein binding regions.
Takeaway
This study helps scientists understand how proteins interact by classifying the areas where they bind to each other.
Methodology
The classification was performed using hierarchical clustering with a similarity index based on overlapping interacting residues.
Limitations
The criteria for defining binding regions can be arbitrary and may differ among protein families.
Digital Object Identifier (DOI)
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