Study on Familial Colorectal Cancer in Sweden
Author Information
Author(s): Hemminki K, Li X
Primary Institution: Department of Biosciences at Novum, Karolinska Institute
Hypothesis
What is the proportion of hereditary nonpolyposis colorectal cancer among familial colorectal cancer cases?
Conclusion
Hereditary nonpolyposis colorectal cancer accounts for 20 to 50% of familial colorectal cancer cases in Sweden.
Supporting Evidence
- 9.82% of families had both an offspring and a parent affected by colorectal cancer.
- The population attributable proportion of familial colorectal cancer was 4.91%.
- The familial standardized incidence ratio was 2.00.
- For proximal colorectal cancer, the standardized incidence ratio was 2.32.
- For distal colorectal cancer, the standardized incidence ratio was 2.00.
- For familial proximal colorectal cancer diagnosed before age 40, the standardized incidence ratio was 25.72.
- Familial risks were also increased for endometrial, small intestinal, and gastric cancers.
Takeaway
This study looked at families in Sweden to see how many had colorectal cancer and found that a significant number of cases are linked to hereditary factors.
Methodology
The study used the nationwide Swedish Family-Cancer Database and calculated standardized incidence ratios for colorectal adenocarcinomas.
Participant Demographics
The study included 9.6 million individuals from the Swedish Family-Cancer Database.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website