Childhood TB in Thailand: Study of Cases and Outcomes
Author Information
Author(s): Lolekha Rangsima, Anuwatnonthakate Amornrat, Nateniyom Sriprapa, Sumnapun Surin, Yamada Norio, Wattanaamornkiat Wanpen, Sattayawuthipong Wanchai, Charusuntonsri Pricha, Sanguanwongse Natpatou, Wells Charles D, Varma Jay K
Primary Institution: Global AIDS Program, Thailand MOPH – U.S. CDC Collaboration
Hypothesis
What are the epidemiological characteristics and treatment outcomes of childhood tuberculosis in Thailand?
Conclusion
Childhood TB is infrequently diagnosed in Thailand, and HIV significantly contributes to the mortality associated with it.
Supporting Evidence
- Only 2% of total TB cases were in children.
- HIV infection was documented in 27% of childhood TB cases.
- The mortality rate for HIV-infected children during TB treatment was significantly higher than for those not known to be HIV-infected.
Takeaway
This study looked at kids with tuberculosis in Thailand and found that many cases go undiagnosed, especially in children with HIV, who are more likely to die from the disease.
Methodology
Data was collected from healthcare facilities in four provinces and one national hospital, focusing on children diagnosed with TB from 2004 to 2006.
Potential Biases
Potential overestimation of childhood TB burden due to higher prevalence in participating provinces.
Limitations
The study had a small sample size and lacked microbiologic confirmation for most cases.
Participant Demographics
Median age of participants was 8 years, with 52% male and 13% non-Thai nationality.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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