Histamine H3 Receptors and Rat Aorta Relaxation
Author Information
Author(s): D. M. Djuric, I. Z. Andjelkovic
Primary Institution: Institute of Physiology, Medical Faculty University of Belgrade
Hypothesis
Are histamine H3 receptors present on rat aorta endothelium and do they play a role in endothelium-dependent responses?
Conclusion
The study found a heterogeneous population of histamine receptors, H1 and H3, on rat aorta endothelium that may participate in endothelium-dependent responses to histamine.
Supporting Evidence
- Histamine induced a concentration-dependent relaxation of rat aorta.
- Removal of the endothelium abolished the relaxation to histamine.
- Pyrilamine and thioperamide shifted the concentration-response curve for histamine-induced relaxation to the right.
- The presence of endothelium is essential for the relaxing effect of histamine.
- Histamine H3 receptors were found to be involved in the feedback control of histamine synthesis and release.
Takeaway
This study looked at how histamine affects blood vessel relaxation in rats and found that certain receptors help control this process.
Methodology
The study involved isolating rat aorta segments and testing their relaxation response to histamine and (R)-MeHA in the presence of various antagonists.
Participant Demographics
Male Wistar rats weighing between 100 and 200g
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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