Thyroid Functions in Long-Term Survivors of Pediatric Hodgkin’s Lymphoma
Author Information
Author(s): Demirkaya Metin, Sevinir Betül, Sağlam Halil, Özkan Lütfi, Akacı Okan
Primary Institution: Uludag University, Medical Faculty, Bursa, Turkey
Hypothesis
The study aimed to evaluate the thyroid functions of long-term survivors of pediatric Hodgkin’s lymphoma treated with chemotherapy and radiotherapy.
Conclusion
Radiation-induced thyroid disorders may develop in pediatric Hodgkin’s lymphoma patients in complete remission starting as early as the first year after treatment and are dose-dependent.
Supporting Evidence
- Thyroid function tests were abnormal in 14 (24.5%) patients.
- Subclinical and overt hypothyroidism was diagnosed in 11 (78.6%) and 3 (21.4%) patients with abnormal thyroid function tests.
- A statistically significant correlation was found between the dose of mantle radiotherapy and thyroid function disorder (p=0.002).
- Nearly one-fourth (21.4%) of all thyroid function disorders were detected in the first year of follow-up.
Takeaway
Kids who survived Hodgkin's lymphoma and got radiation treatment might have thyroid problems later on, especially if they got a lot of radiation.
Methodology
Thyroid functions were evaluated retrospectively in 55 Hodgkin’s lymphoma patients in complete remission.
Limitations
The study had a relatively short follow-up period of 5.54 years, which may not capture all thyroid dysfunctions.
Participant Demographics
The study included 37 males (67.3%) and 18 females (32.3%) with a mean age at diagnosis of 10.35 years.
Statistical Information
P-Value
p=0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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