Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles
2008
5-Fluorouracil Loaded Nanoparticles for Cancer Treatment
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): Li Su, Wang Anxun, Jiang Wenqi, Guan Zhongzhen
Primary Institution: Sun Yat-sen University
Hypothesis
Prolonged circulation of anticancer drugs will increase their anticancer activity while decreasing their toxic side effects.
Conclusion
5-FU/PEG-PBLG nanoparticles changed the pharmacokinetic behavior of 5-FU, thus increasing its anticancer activity.
Supporting Evidence
- 5-FU/PEG-PBLG nanoparticles had a longer elimination half-life compared to 5-FU.
- 5-FU/PEG-PBLG nanoparticles showed greater inhibition of tumor growth than 5-FU.
- The drug loading capacity of the nanoparticles was 27.1%.
Takeaway
Researchers made tiny particles that carry a cancer drug to help it work better and hurt healthy cells less.
Methodology
5-FU loaded PEG-PBLG nanoparticles were prepared and their pharmacokinetics and anticancer effects were studied in mice.
Participant Demographics
New Zealand rabbits and BALB/c nude mice were used in the study.
Statistical Information
P-Value
p < 0.01
Statistical Significance
p < 0.01
Digital Object Identifier (DOI)
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