A new hydrated crystalline form of N-[(E)-(4-hy­droxy­phen­yl)methyl­idene]-1H-1,2,4-triazol-3-amine and its anti­fungal activity
2025

New Hydrated Crystalline Form with Antifungal Activity

Sample size: 3 publication Evidence: moderate

Author Information

Author(s): Boutheina Boualia, Zakaria Bouhidel, Cherouana Aouatef, El-Eulmi Bendeif

Primary Institution: Université Mentouri de Constantine

Hypothesis

The study aims to synthesize and evaluate the antifungal activity of a new Schiff base compound.

Conclusion

The new Schiff base exhibits significant antifungal activity, especially against Alternaria alternata.

Supporting Evidence

  • The compound showed a 72.28% inhibition rate against Alternaria alternata.
  • Fusarium oxysporum exhibited a 36% inhibition rate.
  • Botrytis cinerea showed a 15.33% inhibition rate.

Takeaway

Scientists created a new compound that can help fight off certain fungi that harm plants, and it works really well against one type of fungus.

Methodology

The compound was synthesized through a one-step reflux reaction, and its antifungal activity was evaluated using the agar diffusion method.

Limitations

The study was conducted in vitro, which may not fully represent in vivo conditions.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1107/S205698902401209X

Want to read the original?

Access the complete publication on the publisher's website

View Original Publication