Factors Affecting Mannose-Binding Lectin Levels in American Indians
Author Information
Author(s): Best Lyle G, Ferrell Robert E, DeCroo Susan, North Kari E, MacCluer Jean W, Zhang Ying, Lee Elisa T, Howard Barbara V, Umans Jason, Palmieri Vittorio, Garred Peter
Primary Institution: Missouri Breaks Industries Research Inc
Hypothesis
The study investigates the genetic and environmental factors that influence mannose-binding lectin (MBL) levels in American Indians.
Conclusion
The study presents new data on how genetic variants and clinical factors affect MBL levels in an American Indian population.
Supporting Evidence
- The study confirms the effects of known genetic variants on MBL levels.
- MBL levels were positively associated with male gender and hemoglobin A1c levels.
- MBL levels were inversely related to triglyceride levels.
Takeaway
This study looks at how certain genes and health factors affect a protein called mannose-binding lectin in American Indians, which is important for their immune system.
Methodology
The study used a longitudinal cohort design, analyzing MBL levels through double sandwich ELISA and comparing them across different genotypic groups.
Potential Biases
The study's reliance on self-reported ethnicity and health status may introduce bias.
Limitations
The matching structure of the sample may limit the interpretation of comparisons between cases and controls.
Participant Demographics
Participants included 51 cases and 186 controls, with a majority reporting American Indian heritage.
Statistical Information
P-Value
0.004
Confidence Interval
95% CI 1.5–7.0
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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