Effects of Radiation on White Blood Cell Interaction with Blood Vessels in Tumors
Author Information
Author(s): N.Z. Wu, B.A. Ross, C. Gulledge, B. Klitzman, R. Dodge, M.W. Dewhirst
Primary Institution: Duke University Medical Center
Hypothesis
Radiation would cause increased leucocyte rolling and adhesion in both tumour and normal tissues.
Conclusion
Radiation increased leucocyte rolling and adhesion in normal tissues but decreased it in tumour-bearing tissues.
Supporting Evidence
- Radiation significantly increased leucocyte rolling and adhesion in normal preparations.
- In tumour-bearing preparations, radiation caused a decrease in leucocyte rolling and adhesion.
- Leucocyte interactions with endothelial cells were measured using a rat dorsal skinfold window chamber model.
- Systemic leucocyte count and differential were not significantly affected by radiation.
Takeaway
When radiation is applied, normal tissues have more white blood cells sticking to their blood vessels, while tumor tissues have less.
Methodology
Leucocyte rolling and adhesion were measured in rat skinfold window chambers after exposure to 6 Gy of radiation.
Limitations
The study was limited to a specific animal model and may not generalize to all tumor types.
Participant Demographics
Rats used in the study weighed between 125-150 g and included both normal and adenocarcinoma-bearing groups.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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