Body Size and Survival in Premenopausal Breast Cancer
Author Information
Author(s): E.R. Greenberg, M.P. Vessey, K. McPherson, R. Doll, D. Yeates
Primary Institution: University Department of Community Medicine and General Practice, Radcliffe Infirmary, Oxford, UK
Hypothesis
Is prognosis related to body size or to demographic and reproductive factors in premenopausal breast cancer patients?
Conclusion
Body weight is a strong predictor of survival in premenopausal breast cancer, with heavier women having worse outcomes.
Supporting Evidence
- 228 patients died during the follow-up period.
- Weight was a strong predictor of survival, with a significant trend towards lower survival with increasing weight.
- 62% of patients had clinical stage I tumors at first presentation.
Takeaway
The study found that heavier women with breast cancer tend to survive less time than lighter women.
Methodology
The study analyzed survival data from 582 premenopausal women diagnosed with breast cancer, focusing on body weight and other demographic factors.
Potential Biases
Potential bias in clinical staging and selection of participants may affect the results.
Limitations
The study may have selection bias due to the clinical stage distribution of tumors and the exclusion of certain patients.
Participant Demographics
Women aged up to 50 years, all premenopausal at diagnosis.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Want to read the original?
Access the complete publication on the publisher's website