Fangshan Family-based Ischemic Stroke Study Protocol
Author Information
Author(s): Tang Xun, Hu Yonghua, Chen Dafang, Zhan Siyan, Zhang Zongxin, Dou Huidong
Primary Institution: Peking University School of Public Health
Hypothesis
What genetic factors predispose individuals to ischemic stroke?
Conclusion
The FISSIC program aims to identify genetic and environmental factors contributing to ischemic stroke in a rural Chinese population.
Supporting Evidence
- The study aims to fill the gap in family-based genetic studies of ischemic stroke in developing countries.
- It will collect DNA samples from a large cohort of ischemic stroke pedigrees.
- The study design includes both family-based and matched case-control components.
Takeaway
This study is trying to find out what genes make people more likely to have a stroke, especially in families.
Methodology
The study uses a family-based design to recruit ischemic stroke probands and their relatives, collecting blood samples and health data for analysis.
Potential Biases
Potential misclassification bias due to reliance on self-reported stroke history.
Limitations
The study does not use the NIHSS to classify stroke severity and lacks a genome-wide linkage screen.
Participant Demographics
Participants are mainly native Han Chinese from rural areas of northern China.
Digital Object Identifier (DOI)
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