Cerebral Venous Thrombosis in Children
Author Information
Author(s): Menascu S., Lotan A., Ben Zeev B., Nowak-Gottl U., Kenet G.
Primary Institution: Sheba Medical Center, Tel Hashomer, Israel
Hypothesis
The etiology and pathophysiology of cerebral venous sinus thrombosis (CSVT) in pediatric patients is not fully understood.
Conclusion
Cerebral venous thrombosis in children is a serious condition with significant morbidity and mortality, and its management remains controversial.
Supporting Evidence
- CSVT incidence varies between 0.4 and 0.7 per 100,000 children per year.
- More than 40% of childhood CSVT occurs within the neonatal period.
- Clinical manifestations of CSVT are often non-specific and can be subtle.
- Ultrasound is poor for detecting cerebral infarction and should not be used as the primary detection method for CSVT.
- Anticoagulation therapy is less clear for children compared to adults.
Takeaway
Cerebral venous thrombosis is a rare but serious condition in children that can cause seizures and other problems, and doctors are still figuring out the best ways to treat it.
Methodology
This review summarizes existing literature and studies on the incidence, diagnosis, and management of CSVT in children.
Potential Biases
Potential selection bias due to studies being conducted in referral centers with high clinical awareness.
Limitations
The review highlights the lack of standardized assessment protocols and the variability in reporting outcomes across studies.
Participant Demographics
Children and neonates, with a focus on those hospitalized in tertiary medical centers.
Statistical Information
Confidence Interval
95% CI, 2.44 to 22.42; 95% CI, 4.53 to 16.96; 95% CI, 1.22 to 8.40; 95% CI, 2.59 to 4.10; 95% CI, 1.67 to 3.51; 95% CI, 1.20 to 2.08; 95% CI, 3.67 to 13.14; 95% CI, 4.52 to 8.69; 95% CI, 5.93 to 23.73.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website