Multifocal Choroiditis Mimicking Ocular Histoplasmosis Syndrome
Author Information
Author(s): Hatef Elham, Turkcuoglu Peykan, Ibrahim Mohamed, Sepah Yasir, Shulman Matthew, Heo Jangwon, Lee Jeong Hee, Channa Roomasa, Khwaja Afsheen, Rentiya Zubir, Shah Syed Mahmood, Do Diana V., Nguyen Quan Dong
Primary Institution: Wilmer Eye Institute, Johns Hopkins University School of Medicine
Hypothesis
Can multifocal choroiditis be misdiagnosed as ocular histoplasmosis syndrome?
Conclusion
Multifocal choroiditis may initially appear as ocular histoplasmosis syndrome, and proper diagnosis is crucial for effective treatment.
Supporting Evidence
- Histoplasma antigen/antibody tests were negative in all patients.
- Five patients showed active inflammation confirmed by imaging.
- Visual acuity stabilized or improved in three patients on immunomodulatory therapy.
Takeaway
Some eye problems that look like one disease might actually be another, so doctors need to check carefully to give the right medicine.
Methodology
Retrospective review of nine patients with initial diagnosis of ocular histoplasmosis syndrome, including serology and imaging studies.
Potential Biases
Potential bias due to retrospective nature and limited patient history.
Limitations
The study is retrospective with a small sample size and short follow-up duration.
Participant Demographics
Eight women and one man, aged 26–69 years (median: 38 years).
Digital Object Identifier (DOI)
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