Plasma microRNAs in oesophageal squamous cell carcinoma
Author Information
Author(s): Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Morimura R, Nagata H, Kosuga T, Iitaka D, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E
Primary Institution: Kyoto Prefectural University of Medicine
Hypothesis
Plasma miRNAs concentrations contribute to potential biomarkers in patients with oesophageal squamous cell carcinoma (ESCC).
Conclusion
Detection of circulating miRNAs might provide new complementary tumour markers for ESCC.
Supporting Evidence
- The plasma level of miR-21 was significantly higher in ESCC patients than controls.
- The plasma level of miR-375 was significantly lower in ESCC patients than controls.
- The miR-21/miR-375 ratio was significantly higher in ESCC patients than in controls.
- Patients with high plasma levels of miR-21 tended to show a high correlation with recurrence.
Takeaway
Doctors can look at tiny pieces of RNA in the blood to help find and track oesophageal cancer.
Methodology
The study involved measuring plasma levels of specific miRNAs in 50 ESCC patients and 20 healthy volunteers using quantitative RT-PCR.
Participant Demographics
50 patients with oesophageal squamous cell carcinoma and 20 healthy volunteers.
Statistical Information
P-Value
P=0.0218 for miR-21, P=0.0052 for miR-375, P<0.0001 for miR-21/miR-375 ratio.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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