Alzheimer’s Disease Pathways in Long-Lived Families
Author Information
Author(s): Wojczynski Mary, Cosentino Stephanie, Raghavachari Nalini
Primary Institution: National Institute on Aging
Hypothesis
Are long-lived families protected against dementia and what are the predictors of dementia within these families?
Conclusion
The study explores genetic, environmental, and behavioral factors associated with dementia-free survival in long-lived families.
Supporting Evidence
- The study includes findings on the impact of sampling on polygenic risk scores for dementia.
- Longitudinal changes of lysophosphatidylcholine and its risk for incident AD were examined.
- A multi-omic analysis of the effect of lipids on AD was conducted.
- Analyses of sleep duration in relation to cognition were discussed.
Takeaway
This study looks at families who live a long time to see if they are less likely to get dementia and what helps them stay healthy.
Methodology
The study involved phenotyping individuals from long-lived families and conducting extensive genetic analyses.
Limitations
The symposium discusses limitations related to population polygenic risk scores for dementia.
Participant Demographics
Participants included 4,953 individuals from 539 two-generational families.
Digital Object Identifier (DOI)
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