Antioxidant and Hepatoprotective Effects of Nymphaea candida Extract
Author Information
Author(s): Zhao Jun, Liu Tao, Ma Long, Yan Ming, Gu Zhengyi, Huang Yi, Xu Fang, Zhao Yu
Primary Institution: Zhejiang University
Hypothesis
The extract of Nymphaea candida has antioxidant and hepatoprotective effects against immunological liver injury in vitro.
Conclusion
The study found that Nymphaea candida extract significantly protects rat hepatocytes from immunological liver injury and exhibits strong antioxidant properties.
Supporting Evidence
- Nymphaea candida extract showed significant hepatoprotective effects as evidenced by decreased AST and ALT enzyme activities.
- The ethyl acetate-soluble fraction exhibited the strongest antioxidant capacity with an IC50 value of 12.6 μg/mL for DPPH.
- NCE significantly scavenged superoxide anion, hydroxyl radicals, and hydrogen peroxide in a dose-dependent manner.
- NCE concentrations of 5–200 μg/mL were almost non-toxic to the cells with a TC50 value of 393.65 μg/mL.
Takeaway
This study shows that a flower extract from a plant called Nymphaea candida can help protect the liver and fight off harmful substances.
Methodology
The study used in vitro assays to evaluate the antioxidant activity and hepatoprotective effects of the ethyl acetate extract of Nymphaea candida on primary cultured rat hepatocytes.
Limitations
Further investigations are necessary to verify these activities in vivo.
Participant Demographics
Male Sprague-Dawley rats, 200 ± 20 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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