Antibodies Against Endogenous Retroviruses
Author Information
Author(s): Chisca Mihaela, Larouche Jean‐David, Xing Qi, Kassiotis George
Primary Institution: The Francis Crick Institute
Hypothesis
The study investigates the immunogenicity of endogenous retroviruses (ERVs) and their potential role in various diseases.
Conclusion
The presence of antibodies against ERV antigens is linked to a variety of diseases, including cancer and autoimmune disorders, suggesting a complex role in immune responses.
Supporting Evidence
- ERVs are remnants of ancient viruses that can trigger immune responses.
- Antibodies against ERV proteins have been found in various autoimmune and cancer conditions.
- The immunogenicity of ERV proteins may vary depending on the disease context.
Takeaway
Our bodies have old virus parts that can sometimes confuse our immune system, making it think there's an infection, which can lead to diseases.
Methodology
The review summarizes existing studies on the antibody responses to ERV proteins in various diseases.
Limitations
The precise mechanisms and effects of ERV antibodies in disease contexts are still not fully understood.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website