High-risk HPV Infections in Breast Cancer in Syrian Women
Author Information
Author(s): Akil N, Yasmeen A, Kassab A, Ghabreau L, Darnel A D, Al Moustafa A-E
Primary Institution: Faculty of Medicine, University of Aleppo, Aleppo, Syria
Hypothesis
High-risk human papillomavirus infections could be important risk factors for breast carcinogenesis and metastasis.
Conclusion
High-risk HPV infections are associated with human breast cancer progression in Syrian women.
Supporting Evidence
- 69 out of 113 breast cancer samples were found to be HPV positive.
- 34.78% of HPV positive samples were coinfected with more than one HPV type.
- E6 onco-protein expression was correlated with Id-1 overexpression in 94.25% of invasive breast cancer samples.
Takeaway
This study found that many women with breast cancer in Syria have infections from certain types of HPV, which might make their cancer worse.
Methodology
The study used PCR and tissue microarray analysis to detect high-risk HPV types and their correlation with Id-1 expression in breast cancer samples.
Limitations
The study is limited to a specific geographic location and may not be generalizable to other populations.
Participant Demographics
Median age of participants was 52 years, with a range from 26 to 66 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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