Epidemiology of Nontuberculous Mycobacteria in Patients without HIV Infection in New York City
Author Information
Author(s): Bodle Ethan E., Cunningham Jennifer A., Della-Latta Phyllis, Schluger Neil W., Saiman Lisa
Primary Institution: Columbia University
Hypothesis
What is the incidence and epidemiology of nontuberculous mycobacteria (NTM) disease in patients without HIV infection?
Conclusion
The incidence of nontuberculous mycobacteria disease in patients without HIV is increasing.
Supporting Evidence
- 505 patients had positive NTM cultures; 119 (24%) met the criteria for NTM disease.
- Estimated incidences for positive cultures, all disease, and respiratory tract disease were 17.7, 2.7, and 2.0 per 100,000 persons, respectively.
- More patients with rapidly growing mycobacteria met criteria for disease than did patients with M. avium complex.
Takeaway
This study looked at patients in New York City who got sick from certain germs that are not tuberculosis, and it found that more people are getting sick from these germs.
Methodology
A retrospective study reviewing medical records of patients without known HIV infection and with positive cultures for NTM from 2000–2003.
Potential Biases
Potential bias due to the convenience sample and the exclusion of patients with known HIV infection.
Limitations
The study used a convenience sample, which may not represent the general population, and the incidence rate calculation was likely an underestimate.
Participant Demographics
{"gender":{"female":66,"male":34},"race":{"white":61,"other":null},"age":{"over_60":59,"under_15":8}}
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI 15.2–20.2
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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