Mcl-1 and Apoptosis Resistance in Chlamydia trachomatis-Infected Cells
Author Information
Author(s): Rajalingam Krishnaraj, Sharma Manu, Lohmann Christine, Oswald Monique, Thieck Oliver, Froelich Christopher J., Rudel Thomas
Primary Institution: Max Planck Institute for Infection Biology
Hypothesis
Mcl-1 up-regulation is crucial for maintaining apoptosis resistance in Chlamydia trachomatis-infected cells.
Conclusion
The study demonstrates that Mcl-1 is essential for preventing apoptosis in cells infected with Chlamydia trachomatis.
Supporting Evidence
- Inhibition of MAPK pathways sensitized infected cells to apoptosis.
- Mcl-1 was significantly up-regulated in Chlamydia trachomatis-infected cells.
- Depletion of Mcl-1 reversed the block in mitochondrial outer membrane permeabilization.
Takeaway
Chlamydia bacteria can make infected cells resistant to dying, and they do this by increasing a protein called Mcl-1.
Methodology
The study used RNA interference and chemical inhibitors to analyze the role of Mcl-1 in apoptosis resistance in infected cells.
Limitations
The study did not explore the mechanisms of apoptosis resistance during the late phase of infection.
Statistical Information
P-Value
p≤0.0003
Statistical Significance
p≤0.0003
Digital Object Identifier (DOI)
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