Effects of Open Lung Ventilation on Heart Function in Pigs
Author Information
Author(s): Miranda Dinis Reis, Klompe Lennart, Cademartiri Filippo, Haitsma Jack J, Palumbo Alessandro, Takkenberg Johanna JM, Lachmann Burkhard, Bogers Ad JJC, Gommers Diederik
Primary Institution: Erasmus MC, Rotterdam, The Netherlands
Hypothesis
When atelectasis is minimized by OLC ventilation, cardiac function is not affected despite the higher mean airway pressure.
Conclusion
OLC resulted in significantly improved lung aeration without negatively affecting right or left ventricular afterload.
Supporting Evidence
- OLC led to a significantly lower amount of atelectasis compared to CMV.
- Indicators of RV afterload were not affected by the ventilation strategy.
- CO was significantly lower during OLC ventilation compared to CMV.
Takeaway
Using a special way to help lungs stay open during ventilation can make them work better without hurting the heart.
Methodology
Ten pigs were ventilated using both conventional and open lung ventilation in a randomized cross-over design after lung lavage.
Limitations
The study was conducted on pigs, which may not fully represent human physiology.
Participant Demographics
Pigs weighing approximately 32 kg.
Statistical Information
P-Value
0.36
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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