Effects of Selenium on Cis-Platin Toxicity and Antitumor Activity
Author Information
Author(s): K. Ohkawa, Y. Tsukada, H. Dohzono, K. Koike, Y. Terashima
Primary Institution: Jikei University School of Medicine
Hypothesis
Does co-administration of selenium reduce the toxicity of cis-platin while maintaining its antitumor activity?
Conclusion
Co-administration of selenium with cis-platin allows for higher doses of cis-platin with reduced toxicity.
Supporting Evidence
- The co-administration of selenium increased the 50% lethal dose of cis-platin from 9.3 mg/kg to 17.5 mg/kg.
- Complete remissions of tumors were achieved with several treatment regimens including selenium.
- Nephrotoxicity and myeloid suppression were significantly reduced with selenium co-administration.
Takeaway
This study found that giving selenium with a cancer drug called cis-platin helps the drug work better without making the patient feel as sick.
Methodology
The study used nude mice with human yolk sac tumors to evaluate the effects of cis-platin alone and in combination with selenium.
Limitations
The study was conducted on mice, which may not fully represent human responses.
Participant Demographics
BALB/c female athymic nude mice, 5-6 weeks old.
Statistical Information
P-Value
p<0.01, p<0.001
Statistical Significance
p<0.05
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