Multiple domain insertions and losses in the evolution of the Rab prenylation complex
2007
Evolution of the Rab Prenylation Complex
Sample size: 43
publication
Evidence: moderate
Author Information
Author(s): Rita Rasteiro, Jose B Pereira-Leal
Primary Institution: Instituto Gulbenkian de Ciência
Hypothesis
What are the evolutionary changes in the domain architecture of the Rab prenylation complex across different organisms?
Conclusion
The study found that the Rab prenylation complex has undergone multiple domain insertions and losses throughout evolution.
Supporting Evidence
- The study identified orthologues of the Rab prenylation machinery in 43 organisms.
- Different domain insertions were found in different taxa.
- The results suggest multiple independent events of domain gains and losses.
Takeaway
Scientists looked at how a group of proteins changed over time in different living things, and they found that some parts of these proteins got added or removed.
Methodology
The study involved profiling the domain architecture of the Rab prenylation complex components in 43 organisms and characterizing their phylogenetic relationships.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website