HLA Class II Associations in Myositis
Author Information
Author(s): Chinoy Hector, Salway Fiona, Fertig Noreen, Shephard Neil, Tait Brian D, Thomson Wendy, Isenberg David A, Oddis Chester V, Silman Alan J, Ollier William E, Cooper Robert G
Primary Institution: the UK Adult Onset Myositis Immunogenetic Collaboration (AOMIC)
Hypothesis
HLA class II associations differ between polymyositis and dermatomyositis.
Conclusion
The study found that different HLA class II haplotypes are associated with distinct myositis subtypes and their clinical features.
Supporting Evidence
- HLA-DRB1*03, DQA1*05 and DQB1*02 were associated with increased risk for both PM and DM.
- The HLA-DRB1*03-DQA1*05-DQB1*02 haplotype was strongly associated with ILD.
- HLA-DRB1*07-DQA1*02-DQB1*02 haplotype was associated with risk for anti-Mi-2 antibodies.
- There were no associations with malignancy.
- Different HLA haplotypes influence clinical features in PM and DM.
Takeaway
This study looked at how certain genes affect two types of muscle diseases, showing that different genes are linked to different disease features.
Methodology
A cross-sectional, case-control study comparing HLA class II in cases of PM and DM with normal subjects.
Potential Biases
Multi-centre recruitment may have led to subtype misclassification.
Limitations
Potential misclassification of disease subtypes and underestimation of ILD and malignancy due to the study design.
Participant Demographics
225 UK Caucasian patients aged 18 and older, with 117 having polymyositis and 108 having dermatomyositis.
Statistical Information
P-Value
p = 0.0001
Confidence Interval
95% CI 0.1–0.6
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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