Topical Tacrolimus for Urethral Strictures in Balanitis Xerotica Obliterans
Author Information
Author(s): Muacevic Alexander, Adler John R, Ahmad Ahsan, Imbisat Md Zaid, Khatoon Qurana
Primary Institution: Indira Gandhi Institute of Medical Sciences
Hypothesis
Can topical tacrolimus effectively treat urethral strictures associated with balanitis xerotica obliterans?
Conclusion
Topical application of tacrolimus is a safe and effective treatment for short-segment urethral strictures associated with BXO.
Supporting Evidence
- The mean pre- and post-tacrolimus maximum urinary flow rate improved significantly.
- The mean pre- and post-tacrolimus IPSS scores also showed significant improvement.
- Patients with strictures >2 cm in length did not respond well to tacrolimus and required surgical intervention.
Takeaway
Doctors used a cream called tacrolimus to help men with a specific kind of urethral problem, and it worked well for those with shorter strictures.
Methodology
This was a prospective study on male patients with urethral strictures associated with BXO, treated with topical tacrolimus and evaluated at six weeks and three months.
Limitations
The study is a single-group study with a follow-up of only six months.
Participant Demographics
Male patients aged >18 years with biopsy-proven BXO.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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