mtcPTM: A Database for Protein Phosphorylation Sites
Author Information
Author(s): Jiménez José L, Hegemann Björn, Hutchins James R A, Peters Jan-Michael, Durbin Richard
Primary Institution: Wellcome Trust Sanger Institute
Hypothesis
The mtcPTM database aims to provide a comprehensive resource for understanding protein phosphorylation and its effects on cellular processes.
Conclusion
The mtcPTM database offers a systematic way to analyze and compare protein phosphorylation patterns, revealing insights into their structural and functional implications.
Supporting Evidence
- mtcPTM is an online repository of human and mouse phosphosites.
- The database contains the largest available collection of atomic models of phosphorylatable proteins.
- Phosphorylation sites are found in a heterogeneous range of structural and sequence contexts.
- Modified residues are generally located in flexible or exposed regions.
Takeaway
Scientists created a special online database to help understand how proteins change when they get a phosphate group added to them, which is important for many cell functions.
Methodology
The mtcPTM database integrates data from literature and high-throughput screenings, storing phosphosites with their experimental context in a hierarchical structure.
Limitations
The database currently only explicitly references mass spectrometric data to their experimental sources, and low-throughput data integration is planned for the future.
Digital Object Identifier (DOI)
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