Anti-nucleosome Antibodies in Scleroderma Patients
Author Information
Author(s): de Araújo Francisco Gustavo Mendes e Ferreira, Skare Thelma Larocca, Nisihara Renato M., Utiyama Shirley R.
Primary Institution: Evangelic University Hospital
Hypothesis
Are anti-nucleosome antibodies present in scleroderma patients?
Conclusion
Scleroderma should be considered when diagnosing connective tissue diseases in patients with anti-nucleosome antibodies.
Supporting Evidence
- 5 out of 54 patients tested positive for anti-nucleosome antibodies.
- 1 patient with PM-SSc and 4 with limited form were positive.
- None of the patients with diffuse form tested positive.
Takeaway
This study looked at blood samples from scleroderma patients to see if they had certain antibodies. They found that a small number of patients had these antibodies.
Methodology
Cross-sectional study analyzing blood samples for anti-nucleosome antibodies using ELISA.
Potential Biases
Different detection methods and patient ethnic backgrounds may introduce bias.
Limitations
The study had a small sample size and may not represent all scleroderma patients.
Participant Demographics
54 scleroderma patients, 4 males and 50 females, mean age 49.2 years.
Statistical Information
Statistical Significance
p<0.05
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