Weak D Antigen Study in Blood Donors and Patients
Author Information
Author(s): Muacevic Alexander, Adler John R, Routray Suman S, Ray Gopal K, Sahoo Nirupama, Israel Karunakar Bakki, Tripathy Sukanta, Acharya Devi
Primary Institution: Kalinga Institute of Medical Sciences
Hypothesis
This study aimed to retrospectively analyze the frequency and characteristics of D variant cases encountered during RhD typing in both blood donors and recipients.
Conclusion
The D variant has a high prevalence in eastern India, highlighting the need for accurate identification methods.
Supporting Evidence
- D variants were found in 0.11% of donors and 0.039% of patients.
- 21.7% of D variant cases were females.
- D variants were more common in adult donors aged 25-44 years.
- The odds of a D variant were 8.5 times higher in the AB blood group compared to the A group.
Takeaway
This study found that some blood donors and patients have a weak form of a blood antigen called D, which can cause problems if not identified correctly.
Methodology
A retrospective analysis of blood samples was conducted using RhD typing methods including conventional tube technique and column agglutination technique.
Potential Biases
Potential bias due to reliance on serological methods without molecular typing.
Limitations
The retrospective design may have contributed to underreporting of D variants.
Participant Demographics
The study included blood donors and patients, with a notable frequency of D variants in adult donors aged 25-44 years and surgical patients.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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