Topical Treatment of Upper Tract Urothelial Carcinoma
Author Information
Author(s): Kenneth G. Nepple, Fadi N. Joudi, Michael A. O'Donnell
Primary Institution: University of Iowa
Hypothesis
A select group of patients with upper tract urothelial carcinoma may be appropriate candidates for minimally invasive management.
Conclusion
Topical treatment of upper tract urothelial cancer can be effective for selected patients, but requires careful patient selection and follow-up.
Supporting Evidence
- Topical treatments can be effective for patients who cannot undergo major surgery.
- Patients must be compliant with treatment and follow-up to manage risks of recurrence.
- Different treatment regimens have been used, with BCG being the most common.
Takeaway
Some patients with a specific type of kidney cancer can be treated with a less invasive method instead of major surgery, but they need to be closely monitored.
Methodology
The study reviews literature on topical treatments and describes an office-based approach for administering therapy.
Potential Biases
Selection bias may affect the outcomes due to the heterogeneous patient groups.
Limitations
The study lacks large prospective or randomized data, making the evidence somewhat anecdotal.
Participant Demographics
Patients included those with solitary kidneys, bilateral disease, poor renal function, and carcinoma in situ.
Digital Object Identifier (DOI)
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