Cyclophilin A interacts with diverse lentiviral capsids
2006
Cyclophilin A and its Interaction with Lentiviral Capsids
publication
Evidence: moderate
Author Information
Author(s): Lin Tsai-Yu, Michael Emerman
Primary Institution: University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA
Hypothesis
Cyclophilin A interacts with diverse lentiviral capsids, affecting their infectivity.
Conclusion
CypA binding to lentiviruses is more widespread than previously thought and is evolutionarily important for lentiviral infection.
Supporting Evidence
- Diverse lentiviruses, including FIV and SIVagmTAN, were shown to bind to CypA.
- Mutagenesis studies identified an essential amino acid for FIV interactions with CypA.
- CsA treatment reduced the infectivity of FIV, similar to HIV-1.
Takeaway
Cyclophilin A helps some viruses, like FIV and HIV, infect cells better, and scientists found that this help is more common among different types of these viruses than they thought.
Methodology
The study used genetic and biochemical assays to test the interaction between CypA and various lentiviral capsids.
Digital Object Identifier (DOI)
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