Nickel Coordination Compounds as Inhibitors of Carbonic Anhydrase
Author Information
Author(s): Joaquin Borr&s, Javier Casanova, Teodora Cristea, Adriana Gheorghe, Andrea Scozzafava, Claudiu T. Supuran, Violeta Tudor
Primary Institution: University of Valencia
Hypothesis
The study investigates the inhibitory properties of Ni(II) complexes of hydrazine and heterocyclic sulfonamides on carbonic anhydrase.
Conclusion
The Ni(II) complexes are strong inhibitors of human carbonic anhydrase isozymes CA I and CA II.
Supporting Evidence
- The new complexes were shown to be 1.1 to 5.5 times more active than the free sulfonamides.
- Complex 12 was found to be more than 6000 times more inhibitory towards CA I compared to sezolamide 4.
- The complexes were characterized by various methods including IR and electronic spectra.
- The study demonstrated that metal complexes of sulfonamides are stronger inhibitors of carbonic anhydrase.
Takeaway
The researchers made new compounds that can stop a specific enzyme in our body, which is important for treating certain diseases.
Methodology
The study involved preparing and characterizing Ni(II) complexes using spectroscopic, magnetic, conductimetric, and thermogravimetric methods.
Limitations
The precise structure of the prepared complexes could not be assigned due to the lack of appropriate crystals for X-ray diffraction.
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