Drug-Induced Myocardial Infarction: A Review of Pharmacological Triggers and Pathophysiological Mechanisms
2024

Drug-Induced Myocardial Infarction: A Review of Pharmacological Triggers and Pathophysiological Mechanisms

publication Evidence: moderate

Author Information

Author(s): Boarescu Ioana, Boarescu Paul-Mihai

Primary Institution: Clinical Emergency County Hospital Saint John the New, Romania

Hypothesis

This review aims to explore the diverse drugs and substances that might lead to drug-induced myocardial infarction, focusing on their mechanisms of action and the pathophysiological processes involved.

Conclusion

Drug-induced myocardial infarction is a significant clinical concern stemming from various pharmacological agents that can provoke or exacerbate myocardial ischemia and infarction through multiple mechanisms.

Supporting Evidence

  • Drug-induced myocardial infarction can occur from both prescribed medications and illicit drugs.
  • Various mechanisms such as coronary vasospasm and endothelial dysfunction can lead to myocardial injury.
  • Certain drugs, including NSAIDs and hormonal therapies, have been linked to increased cardiovascular risks.

Takeaway

Some medicines can hurt your heart and cause a heart attack. This study looks at how different drugs can do that and what happens in the body.

Methodology

This is a review article that discusses various pharmacological agents and their potential to induce myocardial infarction.

Limitations

The review does not provide new experimental data but synthesizes existing literature.

Digital Object Identifier (DOI)

10.3390/jcdd11120406

Want to read the original?

Access the complete publication on the publisher's website

View Original Publication