Clinical Signs of Sjogren's Disease in a Dog
Author Information
Author(s): Story Brett D., Thomasy Sara M., Randolph Max W., Vincek Anna, Martins Bianca, Mills Erinn P., Dear Jonathan D., Johnson Eric G., Jordan Richard C., Goldschmidt Stephanie L., Vapniarsky Natalia
Primary Institution: University of California, Davis
Hypothesis
Canine Sjogren's disease can be diagnosed through clinical and immunohistochemical findings.
Conclusion
The study presents a case of Sjogren's disease in a dog, highlighting the importance of various diagnostic methods and the positive response to immunosuppressive therapy.
Supporting Evidence
- The dog exhibited symptoms of dry eye and xerostomia, confirmed by clinical tests.
- Histopathological analysis showed significant inflammatory cell infiltration in the salivary glands.
- The dog responded positively to immunosuppressive therapy with prednisone and leflunomide.
- Ultrasound revealed enlarged salivary glands consistent with Sjogren's disease.
- Positive ANA titer supported the diagnosis of Sjogren's disease.
Takeaway
This study shows that dogs can get a disease similar to Sjogren's syndrome in humans, which makes their mouths and eyes dry. With the right treatment, the dog's symptoms got much better.
Methodology
The case report includes clinical examination, ultrasound, histopathology, and immunohistochemistry to diagnose Sjogren's disease.
Limitations
The study lacks computed tomography imaging to evaluate additional salivary glands.
Participant Demographics
A 3-year-old spayed female German shepherd cross weighing 33.4 kg.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website