DNA Methylation and mRNA Expression of SYN III in Schizophrenia
Author Information
Author(s): Brenda C. Murphy, Richard L. O'Reilly, Shiva M. Singh
Primary Institution: The University of Western Ontario
Hypothesis
Does the methylation of the SYN III gene relate to schizophrenia susceptibility?
Conclusion
The study found that SYN III methylation is not related to schizophrenia in the population sample or in monozygotic twins discordant for the condition.
Supporting Evidence
- The study established mRNA expression of SYN III in 22 adult human brain regions.
- Methylation specificity was assessed in 31 brain regions and 51 blood samples.
- Results showed that methylation patterns were similar in brain and blood samples.
Takeaway
This study looked at a gene called SYN III to see if its changes are linked to schizophrenia, but it found that these changes don't seem to cause the illness.
Methodology
The study analyzed mRNA expression and DNA methylation in 31 brain regions and blood samples from schizophrenia patients and controls.
Limitations
The results are based on a single individual's brain samples, which may not represent the general population.
Participant Demographics
20 schizophrenia patients and 31 unaffected controls.
Statistical Information
P-Value
0.82
Statistical Significance
p = 0.82
Digital Object Identifier (DOI)
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