The Anti-AGEing and RAGEing Potential of Isothiocyanates
Author Information
Author(s): Krisanits Bradley A., Kaur Bhoomika, Fahey Jed W., Turner David P.
Primary Institution: Virginia Commonwealth University
Hypothesis
Isothiocyanates may inhibit advanced glycation end products (AGEs) and their receptor (RAGE) to reduce chronic disease risk.
Conclusion
Isothiocyanates have potential therapeutic effects against chronic diseases by inhibiting the harmful effects of AGEs and RAGE.
Supporting Evidence
- Isothiocyanates have shown antioxidant and anti-inflammatory activities.
- AGE exposure is linked to chronic diseases and is influenced by lifestyle factors.
- Isothiocyanates may disrupt the cycle of AGE-RAGE-induced oxidative stress.
Takeaway
Eating certain vegetables can help your body fight off bad stuff that makes you sick as you get older.
Methodology
This review summarizes existing research on isothiocyanates and their effects on AGEs and RAGE.
Limitations
The review highlights the need for more clinical trials to confirm the effects of isothiocyanates on AGE biogenesis in humans.
Digital Object Identifier (DOI)
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