Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models
1996
Anti-inflammatory effects of Stephania tetrandra S. Moore
publication
Evidence: moderate
Author Information
Author(s): H-S. Kang, Y-H. Kim, C-S. Lee, J-J. Lee, I. Choi, K-H. Pyun
Primary Institution: Korea Research Institute of Bioscience and Biotechnology
Hypothesis
To investigate the anti-inflammatory effects of S. tetrandra S. Moore in vitro and in vivo.
Conclusion
S. tetrandra S. Moore has potent anti-inflammatory and anti-fibrosis effects by reducing IL-6 production.
Supporting Evidence
- S. tetrandra S. Moore inhibited IL-6 production by up to 50%.
- It showed no cytotoxicity at concentrations of 0.1-10 µg/ml.
- It reduced collagen production in rat lung fibroblasts.
- S. tetrandra S. Moore decreased serum GOT and GPT levels in cirrhosis models.
- It suppressed the release of superoxide anion and hydrogen peroxide from human monocytes/macrophages.
Takeaway
This study found that a Chinese herb called S. tetrandra can help reduce inflammation and fibrosis in the body.
Methodology
The study involved in vitro and in vivo experiments to assess the effects of S. tetrandra on IL-6 production and inflammatory mediators.
Statistical Information
Statistical Significance
p<0.05
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