Mapping Genetic Risk for Alcohol Consumption
Author Information
Author(s): Ma Jennie Z, Zhang Dong, Dupont Randolph T, Dockter Michael, Elston Robert C, Li Ming D
Primary Institution: The University of Texas Health Science Center at San Antonio
Hypothesis
What are the genetic susceptibility loci for alcohol dependence?
Conclusion
The study found evidence of genetic susceptibility loci for alcohol dependence on chromosomes 9, 15, and 16.
Supporting Evidence
- The study included 4681 subjects from 329 extended families.
- Multi-point sib-pair regression analysis provided strong evidence for linkage of alcohol dependence to chromosome 9.
- The identified region on chromosome 9 has also been linked to alcohol dependence in other populations.
Takeaway
Scientists looked at families to find genes that might make people more likely to drink too much alcohol. They found some clues on specific parts of our DNA.
Methodology
Genome-wide linkage analyses were performed using data from 329 families with self-reported alcohol consumption.
Potential Biases
Potential bias due to self-reporting of alcohol consumption.
Limitations
The study relied on self-reported alcohol consumption, which may be biased.
Participant Demographics
Participants were from the Framingham Heart Study, predominantly Caucasian Americans.
Statistical Information
P-Value
0.00008
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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