Reactions of Organic Disulfides and Gold(I) Complexes
Author Information
Author(s): Melanie DiLorenzo, Shantheni Ganesh, Lily Tadayon, Jinhua Chen, Mitchell R. M. Bruce, Alice E. Bruce
Primary Institution: University of Maine
Hypothesis
Whether phosphine gold(I) thiolate complexes would react with organic disulfides.
Conclusion
The study found that the rate of reactivity of gold-thiolate complexes with organic disulfides varies significantly, with certain complexes showing much higher reactivity.
Supporting Evidence
- The rate of reactivity of the gold-thiolate complexes was found to correlate with conductivity measurements.
- 1H NMR experiments showed the formation of mixed disulfides during the reactions.
- Electrochemical studies suggested that free thiolate is not involved in the exchange reaction.
Takeaway
This study looks at how certain gold compounds interact with organic substances called disulfides, which are important in biology. It found that some gold compounds react much faster than others.
Methodology
The study involved gold-thiolate/disulfide exchange reactions monitored by NMR and conductivity measurements.
Limitations
The study does not provide specific limitations but suggests that the reactivity may depend on the specific conditions and complexes used.
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