The Role of VGF in Neuropathic Pain
Author Information
Author(s): Moss Andrew, Ingram Rachel, Koch Stephanie, Theodorou Andria, Low Lucie, Baccei Mark, Hathway Gareth J, Costigan Michael, Salton Stephen R, Fitzgerald Maria
Primary Institution: UCL Department of Neuroscience, Physiology and Pharmacology, University College London
Hypothesis
Does the neuropeptide VGF play a role in neuropathic pain following peripheral nerve injury?
Conclusion
VGF expression is highly modulated in nociceptive pathways following peripheral nerve injury and can cause dorsal horn cell excitation and behavioral hypersensitivity in naïve animals.
Supporting Evidence
- VGF mRNA and protein were significantly upregulated in injured dorsal root ganglion neurons.
- Intrathecal application of TLQP-62 caused long-lasting mechanical and cold behavioral allodynia in naïve rats.
- VGF application directly influenced dorsal horn neuron excitability.
Takeaway
VGF is a special protein that changes a lot when nerves are hurt, and it can make animals feel more pain when they touch something cold or painful.
Methodology
The study used a rat spared nerve injury model to examine VGF expression and its effects on sensory neurons.
Participant Demographics
Adult Sprague Dawley rats were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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