Family-Based Association Testing for Kofendred Personality Disorder
Author Information
Author(s): Wang Ming-Hsi, Guo Mitchell, Shugart Yin Y
Primary Institution: Johns Hopkins University
Hypothesis
Can family-based association tests (FBAT) detect associations between SNP markers and the latent trait of Kofendred Personality Disorder?
Conclusion
FBAT was able to detect significant associations for certain SNPs related to Kofendred Personality Disorder with a reasonable power.
Supporting Evidence
- FBAT detected significant associations for SNPs B03T3056, B03T3057, and B03T3058.
- The power to detect significant associations was 98%, 87%, and 71% for the respective SNPs.
- The overall false-positive rate was calculated to be 0.06.
Takeaway
The study used a special test to find links between genes and a personality disorder in families, and it found some strong connections.
Methodology
FBAT was used to test for genetic association in 100 simulated replicates of the Aipotu population.
Potential Biases
Potential biases due to population admixture and the treatment of different nuclear families as independent.
Limitations
The study did not use the '-e' option for multivariate analysis, which could have affected the results.
Participant Demographics
100 nuclear families with an average of 4.8 siblings per family.
Statistical Information
P-Value
0.0002, 0.00072, 0.0038
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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