Phaeochromycins F–H, three new polyketide metabolites from Streptomyces sp. DSS-18
2008
New Polyketide Metabolites from Marine Actinomycete
publication
Evidence: moderate
Author Information
Author(s): Li Jian, Lu Chun-Hua, Zhao Bao-Bing, Zheng Zhong-Hui, Shen Yue-Mao
Primary Institution: Xiamen University
Hypothesis
The study aims to isolate and determine the structures and biological properties of new polyketides from a marine actinomycete.
Conclusion
Three new polyketides, phaeochromycins F, G, and H, were successfully isolated and characterized from Streptomyces sp. DSS-18.
Supporting Evidence
- Phaeochromycins F and G showed weak cytotoxicities with inhibitory rates of 9.4% and 1.0% respectively.
- Phaeochromycin H exhibited a modest inhibitory rate of 46.0% at a concentration of 10 μg/ml.
Takeaway
Scientists found three new substances from a type of bacteria that live in the ocean, and they studied what these substances look like and how they might work.
Methodology
The study involved fermentation of the marine actinomycete, extraction of metabolites, and detailed spectroscopic analyses for structure determination.
Digital Object Identifier (DOI)
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