The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias
2012
The Role of BCL2 Family of Apoptosis Regulator Proteins in Leukemias
publication
Evidence: high
Author Information
Author(s): Tzifi Flora, Economopoulou Christina, Gourgiotis Dimitrios, Ardavanis Alexandros, Papageorgiou Sotirios, Scorilas Andreas
Primary Institution: University of Athens
Hypothesis
The BCL2 family of proteins is related to cancer pathophysiology and resistance to chemotherapy.
Conclusion
Understanding the molecular pathways of BCL2 proteins may lead to new therapies that improve survival in leukemia patients.
Supporting Evidence
- BCL2 family proteins are crucial for regulating apoptosis in leukemia.
- Impaired apoptosis is linked to cancer progression and treatment resistance.
- Different types of leukemia show varied expression of BCL2 family members.
Takeaway
BCL2 proteins help control when cells die, and problems with these proteins can lead to leukemia and make it harder to treat.
Digital Object Identifier (DOI)
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