Translation initiation and its deregulation during tumorigenesis
2002
Translation Initiation and Cancer
publication
Evidence: moderate
Author Information
Author(s): Watkins S J, Norbury C J
Primary Institution: Cancer Research UK Molecular Oncology Laboratory, University of Oxford
Hypothesis
Misregulation of protein synthesis is a major factor in cancer development.
Conclusion
Abnormal regulation of translation initiation is a common feature in tumor development.
Supporting Evidence
- Misregulation of translation factors can lead to excessive protein synthesis.
- eIF4E over-expression is found in many human tumors.
- eIF2α levels are higher in various cancers compared to normal tissues.
- eIF3 subunits are implicated in several types of cancer.
- eIF4G and eIF3 can bind directly to mRNA, enhancing translation.
Takeaway
This study talks about how cells make proteins and how mistakes in this process can lead to cancer.
Digital Object Identifier (DOI)
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